Journal
SLEEP MEDICINE CLINICS
Volume 6, Issue 1, Pages 71-+Publisher
ELSEVIER INC
DOI: 10.1016/j.jsmc.2010.12.004
Keywords
cAMP; PKA; CREB; Learning; Memory; NREM; REM; Oscillation
Categories
Funding
- NIA [AG-18199]
- NIMH [MH-60244]
- NHLBI [HL-60287]
- Whitehall Foundation
- John Merck Foundation
- David and Lucile Packard Foundation
- NSF [0706858]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0706858] Funding Source: National Science Foundation
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The electrophysiological properties of the sleeping brain profoundly influence memory function in various species, yet the molecular nature of sleep-memory interaction remains unclear. This article summarizes work that has established the cAMP-PKACREB intracellular signaling pathway as a major mechanism in the wakeful consolidation of memory while highlighting newer evidence that this pathway has a role in sleep regulation, in sleep deprivation, and potentially in sleep-memory interactions. It also explores the possibility that sleep might influence memory processing during a sort of molecular replay. The role of new approaches in understanding the nature of sleep-memory interactions is also discussed.
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