Journal
JOURNAL OF ANXIETY DISORDERS
Volume 25, Issue 2, Pages 251-257Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.janxdis.2010.09.010
Keywords
Anxiety disorders; Panic disorder; Posttraumatic stress Disorder; Subgenual cingulate cortex; Ventral striatum; Extended amygdala; Brainstem; Neuroimaging
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Funding
- Intramural NIH HHS [Z99 DA999999] Funding Source: Medline
- NIMH NIH HHS [P50 MH58911-S1, P50 MH058911-01A10002, P50 MH058911, P50 MH058911-01A19002] Funding Source: Medline
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Most functional neuroimaging studies of panic disorder (PD) have focused on the resting state, and have explored PD in relation to healthy controls rather than in relation to other anxiety disorders. Here, PD patients, posttraumatic stress disorder (PTSD) patients, and healthy control subjects were studied with functional magnetic resonance imaging utilizing an instructed fear conditioning paradigm incorporating both Threat and Safe conditions. Relative to PTSD and control subjects, PD patients demonstrated significantly less activation to the Threat condition and increased activity to the Safe condition in the subgenual cingulate, ventral striatum and extended amygdala, as well as in midbrain periaquaeductal grey, suggesting abnormal reactivity in this key region for fear expression. PTSD subjects failed to show the temporal pattern of activity decrease found in control subjects. (C) 2010 Elsevier Ltd. All rights reserved.
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