Journal
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
Volume 54, Issue 5, Pages 1520-1528Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ie503831k
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Funding
- National Natural Science Foundation of China [21275127]
- Program for New Century Excellent Talents in Fujian Province University [JA12204]
- Natural Science Foundation of Zhangzhou [ZZ2012J01]
- key laboratory of urban environment and health, institute of urban environment, Chinese Academy of Sciences [KLUEH201305]
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Rugby-ball-shaped CoS2 (rCoS2) submicroparticles have been synthesized via a simple hydrothermal reaction. The rCoS2 submicroparticles were then casted on a glassy carbon electrode and served as a highly conductive and large surface area platform for the electrosynthesis of poly(2-thiophenesulfonyl chloride) (pTSC), using 2-thiophenesulfonyl chloride as the monomer. The stepwise modification process was characterized by attenuated total reflectanceFourier transform infrared spectroscopy (ATR-FTIR) and different electrochemical technologies. The stable pTSC layer was utilized as a functional interface to immobilize amino-modified probe DNA via a facile sulfonylamino condensation reaction, without the assistance of any other cross-linkers. Because of the synergistic effect of rCoS2 and pTSC from the hybrid material, the developed DNA biosensor could detect target DNA over a wide dynamic range, from 1.0 x10(-1)3 to 1.0 x 10(-7) M, with the detection limit down to 1.1 x 10(-14) M. Benefiting from the steady electropolymerization film of pTSC and the stable sulfamide bond between the amino-modified DNA and pTSC, the biosensor also showed high stability, reusability, and reproducibility.
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