Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 41, Issue 2, Pages 248-253Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-010-1040-9
Keywords
PPI; FMR1 gene; Sensorimotor gating; mGluR5; Prepulse inhibition; Startle
Categories
Funding
- NICHD NIH HHS [HD055510] Funding Source: Medline
- NIMH NIH HHS [K23 MH077554, MH77554] Funding Source: Medline
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Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS-A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS-A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.
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