ANTIPYRETIC ACTIVITY OF CRATEVA MAGNA BARK ON TAB- VACCINE INDUCED PYREXIA

Objective: Crataeva magna is a potent medicinal plant in the Indian systems of medicine. Traditionally used for inflammation, fever, arthritis, bronchitis, urinary calculi and cough. The objective of the present work was to study the antipyretic activity of plant Crataeva magna (Lour.) DC belonging to family Capparaceae. Materials & Methods: In the present study the alcoholic extracts of the bark of Crataeva magna were studied for their antipyretic activity by TAB (Typhoid) vaccine-induced pyrexia in rabbits. Result: In TAB vaccine-induced fever, the fever was significantly reduced and the body temperature was normalized by administration of 200 and 400 mg/kg dose orally and the property was comparable to the reference drug. Conclusion: This study has established the antipyretic activity of Crataeva magna and thus, justifies the anecdotal, folkloric and ethnomedical uses of this plant for fever.