Journal
NATURE REVIEWS IMMUNOLOGY
Volume 11, Issue 4, Pages 289-295Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2959
Keywords
-
Categories
Funding
- British Biotechnology and Biological Sciences Research Council
- Wellcome Trust
Ask authors/readers for more resources
Can the immune system be reactivated continuously throughout the lifetime of an organism or is there a finite point at which repeated antigenic challenge leads to the loss of lymphocyte function or the cells themselves or both? Replicative senescence and exhaustion are processes that control T cell proliferative activity and function; however, there is considerable confusion over the relationship between these two intrinsic cellular control mechanisms. In this Opinion article, we compare the molecular regulation of senescence and exhaustion in T cells. Available data suggest that both processes are regulated independently of each other and that it may be safer to block exhaustion than senescence to enhance immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available