Journal
NATURAL PRODUCT COMMUNICATIONS
Volume 6, Issue 3, Pages 393-402Publisher
NATURAL PRODUCTS INC
Keywords
Marchantins; Bis(bibenzyls); Macrocycles; Total synthesis; Natural products; Liverwort constituents
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [Sp 498/2-1]
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Recently, remarkable microtubule inhibitor and anti-tumor activities of the bis(bibenzyl) marchantin C - isolated from liverworts like Marchantia polymorpha since 1983 - were found. In this paper we describe the efficient total synthesis of this subtype of bis(bibenzylic) compounds with two biarylether connections. Two selectively methylated derivatives known as natural compounds marchantin O and P were synthesized for the first time by modification of the arene subunits and can now be considered as promising highly bioactive compounds.
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