Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 52, Issue 3, Pages 1206-1219Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.10-5599
Keywords
-
Categories
Funding
- National Institutes of Health [R01-EY11610]
- Legacy Good Samaritan Foundation
- Heidelberg Engineering
- Sears Medical Trust
- Royal College of Ophthalmologists/Pfizer
Ask authors/readers for more resources
PURPOSE. To investigate whether longitudinal changes deep within the optic nerve head (ONH) are detectable by spectral domain optical coherence tomography (SDOCT) in experimental glaucoma (EG) and whether these changes are detectable at the onset of Heidelberg Retina Tomography (HRT; Heidelberg Engineering, Heidelberg, Germany)-defined surface topography depression. METHODS. Longitudinal SDOCT imaging (Spectralis; Heidelberg Engineering) was performed in both eyes of nine rhesus macaques every 1 to 3 weeks. One eye of each underwent trabecular laser-induced IOP elevation. Four masked operators delineated internal limiting membrane (ILM), retinal nerve fiber layer (RNFL), Bruch's membrane/retinal pigment epithelium (BM/RPE), neural canal opening (NCO), and anterior lamina cribrosa surface (ALCS) by using custom software. Longitudinal changes were assessed and compared between the EG and control (nonlasered) eyes at the onset of HRT-detected surface depression (follow-up 1; [HA]) and at the most recent image (follow-up 2; [FU2]). RESULTS. Mean IOP in EG eyes was 7.1 to 24.6 nun Hg at FU1 and 13.5 to 31.9 nun Hg at FU2. In control eyes, the mean IOP was 7.2 to 12.6 mm Hg (FLU) and 8.9 to 16.0 'um Hg (FU2). At neuroretinal rim decreased and ALCS depth increased significantly (paired t-test, P < 0.01); no change in RNFL thickness was detected. At FU2, however, significant prelaminar tissue thinning, posterior displacement of NCO, and RNEL thinning were observed. CONCLUSION. Longitudinal SDOCT imaging can detect deep ONH changes in EG eyes, the earliest of which are present at the onset of HRT-detected ONH surface height depression. These parameters represent realistic targets for SDOCT detection of glaucomatous progression in human subjects. (Invest Ophthalmol Vis Se 2011;52:1206-1219) DOI:10.1167/iovs.10-5599
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available