Journal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Volume 52, Issue 5, Pages 2166-2169Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.11-7328
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Funding
- National Institutes of Health Office of the Director
- National Eye Institute
- Research to Prevent Blindness (RPB)
- Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
- Dr. E. Vernon Smith and Eloise C. Smith Macular Degeneration Endowed Chair
- American Health Assistance Foundation
- International Retinal Research Foundation
- Macula Vision Research Foundation
- E. Matilda Ziegler Foundation for the Blind
- Jahnigen Career Development Award
- University of Kentucky
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The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNAs (dsRNAs) in neovascular AMD and cytotoxic functions for endogenous dsRNAs in atrophic AMD. These findings provide new insights into the pathogenesis and therapy of both forms of AMD. (Invest Ophthalmol Vis Sci. 2011;52:2166-2169) DOI:10.1167/iovs.11-7328
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