Journal
ACTA CIRURGICA BRASILEIRA
Volume 28, Issue 5, Pages 367-372Publisher
ACTA CIRURGICA BRASILEIRA
DOI: 10.1590/S0102-86502013000500008
Keywords
Colon; Precancerous Conditions; 1,2-Dimethylhydrazine; Probiotics; Mice
Categories
Funding
- Coordination of Improvement for Higher Academic Staff (CAPES)
- National Council of Technological and Scientific Development (CNPq)
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PURPOSE: To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice. METHODS: The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1-Lactobacillus delbrueckii UFV-H2b20; 2-Bifidobacterium animalis var. lactis Bb12; 3-L. delbrueckii UFV-H2b20 plus B. animalis var. lactis Bb12; and 4-Saccharomyces boulardii) administered orally in drinking water throughout fourteen weeks. RESULTS: Consumption of lactobacilli and bifidobacteria alone resulted in a significant reduction of the total number of aberrant crypt foci (55.7% and 45.1%, respectively). Significant reduction in the number of these small foci (<= 3 aberrant crypts) was only observed in the group treated with lactobacilli (52.2%) in comparison to control group. The number of larger foci (>3 aberrant crypts) crypts had no significant reduction. CONCLUSION: L. delbrueckii UFV-H2b20 and B. animalis var. lactis Bb12 administered alone protect colonic preneoplastic lesions in mice, while the combined treatment of these bacteria and the administration of S. boulardii were not effective in reducing such colonic lesions.
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