Journal
NATURE REVIEWS CANCER
Volume 11, Issue 5, Pages 317-323Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3051
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Funding
- American Cancer Society New England-SpinOdyssey Postdoctoral Fellowship
- US National Cancer Institute (NCI) [R01 CA093665]
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Adherens junctions, which are intercellular adhesive complexes that are crucial for maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour progression. However, the role of desmosomes - adhesion complexes that are related to adherens junctions - in carcinogenesis has remained elusive. Recent studies using mouse genetic approaches have uncovered a role for desmosomes in tumour suppression, demonstrating that desmosome downregulation occurs before that of adherens junctions to drive tumour development and early invasion, suggesting a two-step model of adhesion dysfunction in cancer progression.
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