4.5 Article

Incubation of saccharin craving and within-session changes in responding for a cue previously associated with saccharin

Journal

APPETITE
Volume 72, Issue -, Pages 114-122

Publisher

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.appet.2013.10.003

Keywords

Addiction; Craving; Incubation; Regression; Saccharin; Sucrose

Funding

  1. NIH/NIDA [R15 DA016285-3]
  2. Doshisha University
  3. Western Washington University
  4. Grants-in-Aid for Scientific Research [24530930] Funding Source: KAKEN

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Time-dependent increases in cue-induced sucrose seeking after forced abstinence have been described in rats with a history of sucrose self-administration, suggesting sucrose craving incubates. In the present study, we examined whether the incubation of craving generalizes to the artificial sweetener, saccharin. Thirty-one male Long-Evans rats lever pressed for 0.3% saccharin solution 1 h/day for 10 days. On either Day 1 or 30 of forced abstinence, rats responded for 1 h for presentation of a tone + light cue previously presented with every saccharin delivery during self-administration training. Rats responded more during this cue-reactivity test session following 30 vs. 1 day of forced abstinence (incubation of craving). This result is the first demonstration of the incubation of saccharin craving and suggests that a post-ingestive caloric consequence of self-administration is not a necessary condition for the development of incubation of sucrose craving. We also examined the time course (within-session decreases) of active-lever responding during the 1-h cue-reactivity test session. Rats in the Day 30 group responded more than rats in the Day 1 group from the beginning of the test session. In addition, within-session decreases in responding were shallower in slope in the Day 30 than the Day 1 group. These results indicate that incubation of saccharin craving enhances the persistence of seeking behavior. (C) 2013 Elsevier Ltd. All rights reserved.

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