Journal
NATURE REVIEWS CANCER
Volume 11, Issue 5, Pages 364-374Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3050
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Funding
- Cancer Research UK (CRUK)
- Breast Cancer Campaign, UK
- Cancer Research UK
- CRUK
- Biotechnology and Biological Sciences Research Council (BBSRC), UK
- Biotechnology and Biological Sciences Research Council [D20453] Funding Source: researchfish
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The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates. Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellular signalling, apoptosis and cell survival. Calpain expression is altered during tumorigenesis, and the proteolysis of numerous substrates, such as inhibitors of nuclear factor-kappa B (I kappa B), focal adhesion proteins (including, focal adhesion kinase and talin) and proto-oncogenes (for example, MYC), has been implicated in tumour pathogenesis. Recent evidence indicates that the increased expression of certain family members might influence the response to cancer therapies, providing justification for the development of novel calpain inhibitors.
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