Why is the neurobiology of nausea and vomiting so important?

Nausea and vomiting are important as biological systems for drug side effects, disease co-morbidities, and defenses against food poisoning. vomiting can serve the function of emptying a noxious chemical from the gut, and nausea appears to play a role in a conditioned response to avoid ingestion of offending substances. The sensory pathways for nausea and vomiting, such as gut and vestibular inputs, are generally defined but the problem of determining the brain's final common pathway and central pattern generator for nausea and vomiting is largely unsolved. A neurophysiological analysis of brain pathways provides an opportunity to more closely determine the neurobiology of nausea and vomiting and its prodromal signs (e.g., cold sweating, salivation). (c) 2007 Elsevier Ltd. All rights reserved.