Journal
ACTA BIOMATERIALIA
Volume 10, Issue 5, Pages 2005-2013Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.12.042
Keywords
Collagen porous scaffold; Pore size; Porogen; Ice particulate; Cartilage regeneration
Funding
- World Premier International Research Center Initiative on Materials Nanoarchitectonics
- Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan
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Scaffold pore size is an important factor affecting tissue regeneration efficiency. The effect of pore size on cartilage tissue regeneration was compared by using four types of collagen porous scaffolds with different pore sizes. The collagen porous scaffolds were prepared by using pre-prepared ice particulates that had diameters of 150-250, 250-355, 355-425 and 425-500 mu m. All the scaffolds had spherical large pores with good interconnectivity and high porosity that facilitated cell seeding and spatial cell distribution. Chondrocytes adhered to the walls of the spherical pores and showed a homogeneous distribution throughout the scaffolds. The in vivo implantation results indicated that the pore size did not exhibit any obvious effect on cell proliferation but exhibited different effects on cartilage regeneration. The collagen porous scaffolds prepared with ice particulates 150-250 mu m in size best promoted the expression and production of type II collagen and aggrecan, increasing the formation and the mechanical properties of the cartilage. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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