Journal
ACTA BIOMATERIALIA
Volume 10, Issue 6, Pages 2574-2581Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.02.008
Keywords
Cartilage; Biomechanics; Microstructure; Nonlinear microscopy; Bayesian modeling
Funding
- EPSRC DTA scholarship
- Anthony Coote Equine Research Fund
- Exeter Imaging Networks Bridging the Gaps fund
- Versus Arthritis [19432] Funding Source: researchfish
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Articular cartilage (AC) is a highly anisotropic biomaterial, and its complex mechanical properties have been a topic of intense investigation for over 60 years. Recent advances in the field of nonlinear optics allow the individual constituents of AC to be imaged in living tissue without the need for exogenous contrast agents. Combining mechanical testing with nonlinear microscopy provides a wealth of information about microscopic responses to load. This work investigates the inhomogeneous distribution of strain in loaded AC by tracking the movement and morphological changes of individual chondrocytes using point pattern matching and Bayesian modeling. This information can be used to inform models of mechanotransduction and pathogenesis, and is readily extendable to various other connective tissues. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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