Journal
ACTA BIOMATERIALIA
Volume 10, Issue 7, Pages 2877-2893Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.03.014
Keywords
Heart valve; Tissue engineering; Scaffold; Fiber; Hydrogel
Funding
- HH Sheikh Hamed bin Zayed Al Nahyan Program in Biological Valve Engineering
- Grainger Foundation
- Mayo Clinic Center for Regenerative Medicine
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Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform - the so-called scaffold - is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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