Journal
ACTA BIOMATERIALIA
Volume 10, Issue 6, Pages 2379-2403Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.02.027
Keywords
Metallic medical implants; Biological fluids and tissues; Nanoparticles; In vivo metal ion release; Analytical methodology
Funding
- National Science Centre (NCN), Poland [UMO-2012/06/A/ST4/00382]
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Metal ion release from metallic materials, e.g. metallic alloys and pure metals, implanted into the human body in dental and orthopedic surgery is becoming a major cause for concern. This review briefly provides an overview of both metallic alloys and pure metals used in implant materials in dental and orthopedic surgery. Additionally, a short section is dedicated to important biomaterials and their corrosive behavior in both real solutions and various types of media that model human biological fluids and tissues. The present review gives an overview of analytical methods, techniques and different approaches applied to the measurement of in vivo trace metals released into body fluids and tissues from patients carrying metal-on-metal prostheses and metal dental implants. Reference levels of ion concentrations in body fluids and tissues that have been determined by a host of studies are compiled, reviewed and presented in this paper. Finally, a collection of published clinical data on in vivo released trace metals from metallic medical implants is included. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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