Journal
ACTA BIOMATERIALIA
Volume 10, Issue 11, Pages 4768-4777Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.07.030
Keywords
Biomimetic protein; An16-resilin; Intrinsically disordered protein (IDP); Self-assembly; Multi-stimuli responsiveness
Funding
- Australian Research Council (ARC) [DP0451406, DP1092678]
- Australian Institute of Nuclear Science and Engineering (AINSE) award
- Australian Research Council [DP1092678, DP0451406] Funding Source: Australian Research Council
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Engineered protein polymers that display responsiveness to multiple stimuli are emerging as a promising class of soft material with unprecedented functionality. The remarkable advancement in genetic engineering and biosynthesis has created the opportunity for precise control over the amino acid sequence, size, structure and resulting functions of such biomimetic proteins. Herein, we describe the multi-stimuli-responsive characteristics of a resilin-mimetic protein, An16-resilin (An16), derived from the consensus sequence of resilin gene in the mosquito Anopheles gambiae. We demonstrate that An16 is an intrinsically disordered protein that displays unusual dual-phase thermal transition behavior along with responsiveness to pH, ion, light and humidity. Identifying the molecular mechanisms that allow An16 to sense and switch in response to varying environments furthers the ability to design intelligent biomacromolecules. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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