Journal
ACTA BIOMATERIALIA
Volume 9, Issue 10, Pages 8561-8573Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.01.029
Keywords
Ca20Mg20Zn20Sr20Yb20 alloy; High-entropy alloys; Bulk metallic glasses; Biodegradable metals; Bone
Funding
- National. Basic Research Program of China (973 Program) [2012CB619102]
- National Science Fund for Distinguished Young Scholars [51225101]
- National Natural Science Foundation of China [31170909]
- Research Fund for the Doctoral Program of Higher Education [20100001110011]
- Natural Science Foundation of Heilongjiang Province [ZD201012]
- Guangdong Province innovation RD team project [201001C0104669453]
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In order to enhance the corrosion resistance of the Ca65Mg15Zn20 bulk metallic glass, which has too fast a degradation rate for biomedical applications, we fabricated the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass because of the unique properties of high-entropy alloys. Our results showed that the mechanical properties and corrosion behavior were enhanced. The in vitro tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass could stimulate the proliferation and differentiation of cultured osteoblasts. The in vivo animal tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass did not show any obvious degradation after 4 weeks of implantation, and they can promote osteogenesis and new bone formation after 2 weeks of implantation. The improved mechanical properties and corrosion behavior can be attributed to the different chemical composition as well as the formation of a unique high-entropy atomic structure with a maximum degree of disorder. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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