Journal
ACTA BIOMATERIALIA
Volume 9, Issue 12, Pages 9351-9359Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.07.030
Keywords
Wound healing; Nanofibers; Nanoparticles; Dual-release; Growth factors
Funding
- ARP (Norman Hackerman Advanced Research Program
- National Science Foundation (NSF) Early CAREER Award [DMR 1313553]
- NSF CMMI [1266116]
- National Natural Sciences Foundation of China (NSFC) [31228007]
- National Institute of Health (NIH) [EB012575]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1266116] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1313553] Funding Source: National Science Foundation
Ask authors/readers for more resources
The objective of this research is to develop a dual growth factor-releasing nanoparticle-in-nanofiber system for wound healing applications. In order to mimic and promote the natural healing procedure, chitosan and poly(ethylene oxide) were electrospun into nanofibrous meshes as mimics of extracellular matrix. Vascular endothelial growth factor (VEGF) was loaded within nanofibers to promote angiogenesis in the short term. In addition, platelet-derived growth factor-BB (PDGF-BB) encapsulated poly(lactic-coglycolic acid) nanoparticles were embedded inside nanofibers to generate a sustained release of PDGF-BB for accelerated tissue regeneration and remodeling. In vitro studies revealed that our nanofibrous composites delivered VEGF quickly and PDGF-BB in a relayed manner, supported fibroblast growth and exhibited anti-bacterial activities. A preliminary in vivo study performed on normal full thickness rat skin wound models demonstrated that nanofiber/nanoparticle scaffolds significantly accelerated the wound healing process by promoting angiogenesis, increasing re-epithelialization and controlling granulation tissue formation. For later stages of healing, evidence also showed quicker collagen deposition and earlier remodeling of the injured site to achieve a faster full regeneration of skin compared to the commercial Hydrofera Blue (R) wound dressing. These results suggest that our nanoparticle-in-nanofiber system could provide a promising treatment for normal and chronic wound healing. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available