4.8 Article

Magnesium degradation as determined by artificial neural networks

Journal

ACTA BIOMATERIALIA
Volume 9, Issue 10, Pages 8722-8729

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2013.02.042

Keywords

Magnesium degradation; Implants; In vitro; Cell culture conditions; Artificial neural networks

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Magnesium degradation under physiological conditions is a highly complex process in which temperature, the use of cell culture growth medium and the presence of CO2, O-2 and proteins can influence the corrosion rate and the composition of the resulting corrosion layer. Due to the complexity of this process it is almost impossible to predict the parameters that are most important and whether some parameters have a synergistic effect on the corrosion rate. Artificial neural networks are a mathematical tool that can be used to approximate and analyse non-linear problems with multiple inputs. In this work we present the first analysis of corrosion data obtained using this method, which reveals that CO2 and the composition of the buffer system play a crucial role in the corrosion of magnesium, whereas O-2, proteins and temperature play a less prominent role. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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