Journal
ACTA BIOMATERIALIA
Volume 9, Issue 4, Pages 6123-6133Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2012.12.024
Keywords
Polyelectrolyte capsule; PH-responsive; Intravenous administration; Bovine serum albumin; Layer-by-layer
Funding
- National Natural Science Foundation of China [30973647]
- Zhejiang Provincial Natural Science Foundation of China [Y2100418]
- National Basic Research Program of China (973 Program) [2009 CB930300]
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Polyelectrolyte multilayer capsules, promising candidates for multifunctional drug delivery systems, have recently received increased interest. However, the low encapsulation efficiency of drugs and the lack of reports about animal experiments have greatly slowed down their development for drug delivery. Here, a polyelectrolyte multilayer capsule filled with bovine serum albumin gel (BSA-gel-capsule) was constructed by a layer-by-layer assembly technique and thermally induced gelation of BSA. Owing to the charge variability of BSA with change in pH, BSA-gel-capsules not only showed a pronounced accumulation effect of drugs into capsules, but also displayed excellent pH-controlled loading and release properties. Moreover, a remarkable targeting action to the lung was discovered after intravenous injection of fluorescein isothiocyanate (FITC)-labeled BSA-gel-capsules into mice. After treatment with doxorubicin-loaded BSA-gel-capsules, effective cytotoxicity against B16-F10 cells and inhibition of the pulmonary melanoma growth were revealed. This paper introduces a new type of smart microstructure with notable pH-responsive ability. This material renders feasible the intravenous administration of polyelectrolyte microcapsules, which will be a big step towards their application as drug delivery vehicles. Crown Copyright (C) 2012 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. All rights reserved.
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