Journal
ACTA BIOMATERIALIA
Volume 8, Issue 9, Pages 3429-3435Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2012.06.003
Keywords
Controlled release; Mesoporous; Silica; Trypsin inhibitor; Poly(ethylene glycol)
Ask authors/readers for more resources
With the goal of achieving constant release of large biological molecules over an extended period of time we focused on hybrid inorganic/organic nanoparticles. We synthesized poly(ethylene glycol) (PEG)coated mesoporous silica nanoparticles (MSNs) with incorporated trypsin inhibitor (TI), a model protein molecule for growth factors. Due to the goal of incorporating large protein molecules the pore size of the as-synthesized MSNs was expanded by a hydrothermal treatment prior to TI incorporation. In vitro release from the MSNs without the thin polymer film shows an initial burst followed by continuous release. In the case of polymer-coated MSNs the initial burst release was completely suppressed and approximate zero order release was achieved for 4 weeks. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available