Journal
ACTA BIOMATERIALIA
Volume 8, Issue 4, Pages 1401-1421Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2011.11.017
Keywords
Calcium phosphate nanoparticles; Coatings; Scaffolds; Cements; In vitro and in vivo studies
Funding
- National Institute of Health, NIBIB [NIH-R01-EB-007351]
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Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility. In recent years, CaPs, especially hydroxyapatite and tricalcium phosphate, have attracted significant interest in simultaneous use as bone substitute and drug delivery vehicle, adding a new dimension to their application. CaPs are more biocompatible than many other ceramic and inorganic nanoparticles. Their biocompatibility and variable stoichiometry, thus surface charge density, functionality, and dissolution properties, make them suitable for both drug and growth factor delivery. CaP matrices and scaffolds have been reported to act as delivery vehicles for growth factors and drugs in bone tissue engineering. Local drug delivery in musculoskeletal disorder treatments can address some of the critical issues more effectively and efficiently than the systemic delivery. CaPs are used as coatings on metallic implants, CaP cements, and custom designed scaffolds to treat musculoskeletal disorders. This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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