Journal
ACTA BIOMATERIALIA
Volume 8, Issue 8, Pages 2911-2918Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2012.04.026
Keywords
Degradable; Polymer; Sebacic acid; Poly(ethylene sebacate); Poly(butylene sebacate)
Funding
- WCU Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [R31-10069]
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High molecular weight biodegradable polyesters were prepared from sebacic acid, ethylene glycol and butylene glycol through a simple non-solvent polycondensation with a low toxicity catalyst. The successful synthesis of the polyesters was confirmed by gel permeation chromatography, H-1-nuclear magnetic resonance and Fourier transform-infrared spectroscopies and differential scanning calorimetry. The degradation tests were performed at 37 degrees C in phosphate buffer solution (pH 7.4) and showed a mass loss of similar to 5% over 12 weeks compared with only 2% for polycaprolactone (PCL). Reverse transcription polymerase chain reaction results following culture of osteoblasts on the polymer surface showed that poly(ethylene sebacate) and poly(butylene sebacate) films were optimal for osteoblast formation in terms of Runx 2 and osteocalcin gene expression. (c) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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