Journal
ACTA BIOMATERIALIA
Volume 8, Issue 6, Pages 2243-2253Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2012.03.004
Keywords
Nanocomposite; Polyurethane; Silicate; Organosilicate; Biostability
Funding
- Faculty of Engineering from University of New South Wales
- Australian Research Council [DP0558561]
- Australian Research Council [DP0558561] Funding Source: Australian Research Council
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Organically modified layered silicates were incorporated into a polyether soft-segment polyurethane to form composites of at least delaminated morphology. The primary organic modifier was a quaternary ammonium compound; however, one composite included an alternative amino undecanoic acid-modified silicate. The composites' biostability was assessed in an in vivo ovine model over a period of 6 weeks. Attenuated total reflectance-Fourier transform infrared analysis and semi-quantitative scanning electron microscopy image rating indicate a significant enhancement of the bass polyurethane biostability with the inclusion of silicate at 3 wt.%. The potential effect at 15 wt.% was confounded by probable leaching of the quaternary ammonium compound affecting the tissue response. The amino undecanoic acid composite compared favourably with the quaternary ammonium compound composite of equivalent silicate loading, and offers the promise of a more favourable tissue response. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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