Journal
ACTA BIOMATERIALIA
Volume 7, Issue 2, Pages 585-592Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.08.029
Keywords
Hyperbranched polyglycerol; beta-Cyclodextrin; Hydrophobic drug; Biocompatibility; Multimicelle aggregate
Funding
- Natural Science Foundation of Tianjin [08JCYBJC00300]
- Ph.D. Programs Foundation for New Teachers of the Ministry of Education of China [200800551030]
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The development of successful formulations for poorly water soluble drugs remains a longstanding, critical, and challenging issue in cancer therapy. A beta-cyclodextrin (CD) functionalized hyperbranched polyglycerol (HPG) has been prepared as a potential water insoluble drug carrier. The HPG-g-CD molecules could self-assemble into multimolecular spherical micelles in water, the size of which ranged from 200 to 300 nm, with good dispersity. A high loading capacity and high encapsulation efficiency of paclitaxel, as a model, were obtained. The release profiles of different co-polymer compositions showed a burst release followed by continuous extended release. Furthermore. MTT analysis showed that HPG-g-CD had good biocompatibility, indicating that HPG-g-CD may be considered a promising hydrophobic drug delivery system. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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