Journal
ACTA BIOMATERIALIA
Volume 7, Issue 5, Pages 2015-2028Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.12.024
Keywords
Bacterial adhesion; Biofunctional coatings; Plasma modification; Anti-fouling coatings; Organic polymers
Funding
- Advanced Manufacturing Co-operative Research Centre (AMCRC)
- Australian Postgraduate Award (APA)
- Australian Institute of Nuclear Science and Engineering Postgraduate Award (AINSE PGRA)
- Rural Industry Research and Development Corporation (RIRDC)
- Department of Agriculture, Fisheries and Forestry of Australia (DAFF)
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Despite many synthetic biomaterials having physical properties that are comparable or even superior to those of natural body tissues, they frequently fail due to the adverse physiological reactions they cause within the human body, such as infection and inflammation. The surface modification of blomaterials is an economical and effective method by which biocompatibility and biofunctionality can be achieved while preserving the favorable bulk characteristics of the biomaterial, such as strength and inertness Amongst the numerous surface modification techniques available, plasma surface modification affords device manufacturers a flexible and environmentally friendly process that enables tailoring of the surface morphology, structure, composition, and properties of the material to a specific need There are a vast range of possible applications of plasma modification in biomaterial applications, however, the focus of this review paper is on processes that can be used to develop surface morphologies and chemical structures for the prevention of adhesion and proliferation of pathogenic bacteria on the surfaces of in-dwelling medical devices. As such, the fundamental principles of bacterial cell attachment and biofilm formation are also discussed. Functional organic plasma polymerised coatings are also discussed for their potential as biosensitive interfaces, connecting inorganic/metallic electronic devices with their physiological environments. (C) 2010 Acts Materialia Inc. Published by Elsevier Ltd All rights reserved.
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