Journal
ACTA BIOMATERIALIA
Volume 7, Issue 2, Pages 568-577Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.09.015
Keywords
Poly(ethylene oxide); Layered silicate; Laponite clay; Nanocomposite; Cell adhesion
Funding
- NSF [DMR-0711783]
- Purdue Research Foundation
- Purdue Lynn Doctoral fellowship
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The in vitro cytocompatibility of silicate (Laponite (R) clay) cross-linked poly(ethylene oxide) (PEO) nanocomposite films using MC3T3-E1 mouse preosteoblast cells was investigated while cell adhesion, spreading, proliferation and mineralization were assessed as a function of film composition. By combining the advantageous characteristics of PEO polymer (hydrophilic, prevents protein and cell adhesion) with those of a synthetic and layered silicate (charged, degradable and potentially bioactive) some of the physical and chemical properties of the resulting polymer nanocomposites could be controlled. Hydration, dissolution and mechanical properties were examined and related to cell adhesion. Overall, this feasibility study demonstrates the ability of using model Laponite cross-linked PEO nanocomposites to create bioactive scaffolds. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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