Journal
ACTA BIOMATERIALIA
Volume 7, Issue 11, Pages 3813-3828Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2011.07.002
Keywords
Nanoscale biocomposites; Hydroxyapatite; Polymer; Highly porous; Bone regeneration
Funding
- World Class University through the Korea Science and Engineering Foundation
- Ministry of Education, Science and Technology [R33-2008-000-10021-0]
- National Fisheries Research and Development Institute [K20091003000, FY2009, 20100434961-00]
- Ministry of Education, Science & Technology (MoST), Republic of Korea [R33-2008-000-10021-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Tissue engineering utilizes expertise in the fields of materials science, biology, chemistry, transplantation medicine, and engineering to design materials that can temporarily serve in a structural and/or functional capacity during regeneration of a defect. Hydroxyapatite (HAp) scaffolds are among the most extensively studied materials for this application. However, HAp has been reported to be too weak to treat such defects and, therefore, has been limited to non-load-bearing applications. To capitalize the advantages of HAp and at the same time overcome the drawbacks nanocrystalline HAp (nHAp) is combined with various types of bioactive polymers to generate highly porous biocomposite materials that are used for osteoconduction in the field of orthopedic surgery. In this study we have reviewed nanosized HAp-based highly porous composite materials used for bone tissue engineering, introduced various fabrication methods to prepare nHAp/polymer composite scaffolds, and characterized these scaffolds on the basis of their biodegradability and biocompatibility through in vitro and in vivo tests. Finally, we provide a summary and our own perspectives on this active area of research. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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