Journal
ACTA BIOMATERIALIA
Volume 7, Issue 6, Pages 2374-2383Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2011.02.026
Keywords
Blood clots; Poisson's ratio; Constitutive model; Viscoelasticity; Nanomechanics
Funding
- Natural Sciences and Engineering Research Council of Canada
- Nano/Bio Interface Center at the University of Pennsylvania through the National Science Foundation [NSEC DMR08-32802]
- NIH [HL 030954, HL 090774]
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We describe the mechanical behavior of isotropic fibrin networks at the macroscopic scale in terms of the nanoscale force response of fibrin molecules that are its basic building blocks. We show that the remarkable extensibility and compressibility of fibrin networks have their origins in the unfolding of fibrin molecules. The force-stretch behavior of a single fibrin fiber is described using a two-state model in which the fiber has a linear force-stretch relation in the folded phase and behaves like a worm-like-chain in the unfolded phase. The nanoscale force-stretch response is connected to the macro-scale stress-stretch response by means of the eight-chain model. This model is able to capture the macroscopic response of a fibrin network in uniaxial tension and appears remarkably simple given the molecular complexity. We use the eight-chain model to explain why fibrin networks have negative compressibility and Poisson's ratio greater than 1 due to unfolding of fibrin molecules. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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