Journal
ACTA BIOMATERIALIA
Volume 7, Issue 1, Pages 441-446Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.09.006
Keywords
Magnesium; Conducting polymers; Electrodeposition; Ionic liquid; Controlled drug release
Funding
- National Science Foundation [0748001, 0729869, ERC-0812348]
- National Institute of Health [R01NS062019, 1R21EB008825]
- Department of Defense TATRC [WB1XWH-07-1-0716]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB008825] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS062019] Funding Source: NIH RePORTER
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A conducting polymer-based smart coating for magnesium (Mg) implants that can both improve the corrosion resistance of Mg and release a drug in a controllable way is reported. As the ionic liquid is a highly conductive and stable solvent with a very wide electrochemical window, the conducting polymer coatings can be directly electrodeposited on the active metal Mg in ionic liquid under mild conditions, and Mg is highly stable during the electrodeposition. The electrodeposited poly(3,4-ethylenedioxythiophene) (PEDOT) coatings on Mg are uniform and can significantly improve the corrosion resistance of Mg. In addition, the PEDOT coatings can load the anti-inflammatory drug dexamethasone during the electrodeposition, which can be subsequently released upon electric stimulation. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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