Journal
ACTA BIOMATERIALIA
Volume 6, Issue 9, Pages 3665-3675Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2010.03.034
Keywords
Biocomposite; Alginate; Hydroxyapatite; Calcium carbonate; Nanostructure
Funding
- Research Council of Norway [182047]
- Norwegian Foundation for Health and Rehabilitation via The Norwegian Diabetes Association
- NTNU Nano lab
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A one-step method was used to make nanostructured composites from alginate and calcium carbonate or calcium phosphate. Nanometer-scale mineral phase was successfully formed within the gel network of alginate gel beads, and the composites were characterized. It was found that calcite was the dominating polymorph in the calcium carbonate mineralized beads, while stoichiometric hydroxyapatite was formed in the calcium phosphate mineralized beads. A combination of electron microscopy, Fourier-transform infrared spectroscopy, thermogravimetric analysis and powder X-ray diffraction showed that alginate played an active role in controlling mineral size, morphology and polymorphy. For the calcium phosphate mineralized beads, alginate was shown to modulate stoichiometric hydroxyapatite with low crystallinity at room temperature, which may have important applications in tissue engineering. The results presented in this work demonstrate important aspects of alginate-controlled crystallization, which contributes to the understanding of composite material design. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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