Journal
ACTA BIOMATERIALIA
Volume 6, Issue 3, Pages 750-755Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.08.012
Keywords
Carbonate; Electrospraying; Nanoapatites; Osteoblasts; Silicon
Funding
- Engineering and Physical Sciences Research Council, United Kingdom [GR/S97873, GR/S97880]
- Ministry of Education Academic Research, Singapore [R-265-000-311-133]
- EPSRC [EP/E045839/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [GR/S97880/01, GR/S97880/02, EP/E045839/1] Funding Source: researchfish
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A new deposition method is presented, based on electrospraying, that can build bioceramic structures with desirable surface properties This technology allows nanoapatite crystals, including hydroxyapatite (nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on glass substrates Human osteoblast cells cultured on nSiHA showed enhanced cell attachment, proliferation and protein expression, namely alkaline phosphatase, type I collagen and osteocalcin, as compared to nHA and nCHA. The modification of nanoapatite by the addition of silicon into the HA lattice structure renders the electrosprayed surface more hydrophilic and electronegatively charged (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd All rights reserved
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