Journal
ACTA BIOMATERIALIA
Volume 5, Issue 5, Pages 1798-1807Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.01.005
Keywords
Fluoridated hydroxyapatite; Electrochemical deposition; Dissolution rate; Cellular responses
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Hydroxyapatite (HA) and fluoridated hydroxyapatite (FHA) coatings were deposited on titanium substrates using an electrochemical technique. Different concentrations of F- ions were incorporated into the apatite structure by adding NaF into the electrolyte. Typical apatite structures were obtained for all the coatings after electrodeposition and subsequent post-treatment, including alkaline immersion and vacuum calcination. The coatings were uniform and dense, with a thickness of similar to 5 mu m. When the F-concentration was higher than 0.012 M in the electrolyte, a saturation of F in the coating occurred and the F/Ca ratio in the coatings became almost constant (F/Ca ratio = 0. 125). The FHA coatings showed higher bonding strength and lower dissolution rate than HA coating, particularly for those with a fluoridation level of 0.5-0.625. Compared with pure Ti, FHA and HA coatings exhibited higher biological affinity like cell proliferation and alkaline phosphatase activity. Regarding clinical application, it is suggested that a moderate content of F, such as Ca-5(PO4)(3)(OH)(0.375-0.5)F0.5-0.625, be most suitable as a compromise among cell attachment, cell proliferation, apatite deposition and dissolution resistance. (c) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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