Journal
ACTA BIOMATERIALIA
Volume 5, Issue 5, Pages 1433-1441Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.01.007
Keywords
Titanium; Nanotopography; Mesenchymal stem cell; In vitro test
Funding
- BBSRC
- EPSRC
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Surface nanotopography is known to influence the interaction of human skeletal (mesenchymal) stem cells (hMSC) with a material 14 surface. While most surface nanopatterning has been performed on polymer-based surfaces there is a need for techniques to produce well-defined topography features with tuneable sizes on relevant load-bearing implant materials such as titanium (Ti). In this study titania nanopillar structures with heights of either 15, 55 or 100 nm were produced on Ti surfaces using anodization through a porous alumina mask. The influence of the surface structure heights on hMSC adhesion, spreading, cytoskeletal formation and differentiation was examined. The 15 nm high topography features resulted in the greatest cell response with bone matrix nodule forming on the Ti surface after 21 days. (c) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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