Journal
ACTA BIOMATERIALIA
Volume 5, Issue 8, Pages 3150-3156Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.04.001
Keywords
Brushite; Calcium phosphate cement; Cohesion; Hyaluronic acid; Molecular weight
Funding
- Ministry of Science and Technology [MAT2006-13646-C03-01]
- BSCH-UCM Program
- Spanish Agency for International Cooperation [AECI/A011152/07]
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The improvement of calcium phosphate cement (CPC) cohesion is essential for its application in highly blood perfused regions. This study reports the effectiveness of hyaluronic acids of different molecular weights in the enhancement of brushite cement cohesion. The cement was prepared using a powder phase composed of a mixture of beta-tricalcium phosphate and monocalcium phosphate monohydrate, whereas the liquid phase was formed by 0.5 M citric acid solution modified by the addition of hyaluronic acid of different molecular weights. It was found that medium and high molecular weight hyaluronic acid enhances the cement cohesion and scarcely affects the cement mechanical properties. However, concentrations >0.5% (w/v) were less efficient to prevent the cement disintegration. It is concluded that hyaluronic acid could be applied efficiently to reduce brushite cement disintegration. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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