Journal
ACTA BIOMATERIALIA
Volume 5, Issue 1, Pages 115-123Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2008.08.006
Keywords
Chitosan; Inorganic nanoparticles; Hydrogels; Biomineralization; Stimuli-responsive
Funding
- FCT [POCTI/FIS/61621/2004, PTDC/QUI/69263/2006]
Ask authors/readers for more resources
There is increasing interest in the development of new tissue engineering strategies to deliver cells and bioactive agents encapsulated in a biodegradable matrix through minimally invasive procedures. The present work proposes to combine chitosan-beta-glycerophosphate salt formulations with bioactive glass nanoparticles in order to conceive novel injectable thermo-responsive hydrogels for orthopaedic, reconstructive and regenerative medicine applications. The initial theological properties and the gelation points of the developed organic-inorganic in situ thermosetting systems were revealed to be adequate for intracorporal injection. In vitro bioactivity tests, using incubation protocols in simulated body fluid (SBF), allowed the observation of bone-like apatite formation in the hydrogel formulations containing bioactive nanoparticles. The density of the apatite formed increased with increasing bioactive glass content and soaking time in SBF. These results indicate that the stimuli-responsive hydrogels could potentially be used as temporary injectable scaffolds in bone tissue engineering applications. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available