Journal
ACTA BIOMATERIALIA
Volume 5, Issue 1, Pages 338-345Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2008.07.023
Keywords
Size effect; Nano-hydroxyapatite; Osteoblast-like cells; Cell proliferation; Cell apoptosis
Funding
- Health Ministry of Zhejiang province, China [2008QN018]
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Nano-hydroxyapatite (nano-HAP) may be a better candidate for an apatite substitute of bone in biomedical applications than microsized hydroxyapatite (m-HAP). However, size control is always difficult when synthesizing well-defined nano-HAP particles. In this study, nano-HAP particles with diameters of similar to 20 nm (np20) and similar to 80 nm (np80) were synthesized and characterized. The size effects of these nano-HAPs and m-HAP were studied on human osteoblast-like MG-63 cells in vitro. Our results demonstrate that both cell proliferation and cell apoptosis are related to the size of the HAP particles. Np20 has the best effect on promotion of cell growth and inhibition of cell apoptosis. This work provides an interesting view of the role of nano-HAPs as ideal biomedical materials in future clinical applications. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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