Journal
ACTA BIOMATERIALIA
Volume 5, Issue 3, Pages 817-831Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2008.09.018
Keywords
Self-assembly; Parenteral delivery; Peptide hydrogel; Block copolymer
Funding
- National Institutes of Health Grant (NIDCR) [R01-DE016386-01]
- NATIONAL CANCER INSTITUTE [ZIABC011313] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE016386] Funding Source: NIH RePORTER
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A growing number of medications must be administered through parenteral delivery, i.e., intravenous, intramuscular, or subcutaneous injection, to ensure effectiveness of the therapeutic. For some therapeutics, the use of delivery vehicles in conjunction with this delivery mechanism can improve drug efficacy and patient compliance. Macromolecular self-assembly has been exploited recently to engineer materials for the encapsulation and controlled delivery of therapeutics. Self-assembled materials offer the advantages of conventional crosslinked materials normally used for release, but also provide the ability to tailor specific bulk material properties, such as release profiles, at the molecular level via monomer design. As a result, the design of materials from the bottom up approach has generated a variety of supramolecular devices for biomedical applications. This review provides an overview of self-assembling molecules, their resultant structures, and their use in therapeutic delivery. It highlights the current progress in the design of polymer- and peptide-based self-assembled materials. (c) 2008 Acta Materialia. Inc. Published by Elsevier Ltd. All rights reserved.
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