Journal
ACTA BIOMATERIALIA
Volume 5, Issue 8, Pages 3031-3037Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2009.05.003
Keywords
BSA microspheres; Sonochemistry; Gemcitabine; Renal cancer 786-O cells; Drug delivery
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This report demonstrates the formation and characterization of sonochemically prepared bovine serum albumin (BSA)-Gemzar (Gemcitabine) microspheres and shows their increased anticancer activity compared to pristine Gemzar. The amount of loaded Gemzar was determined by light absorption measurements. The BSA-Gemzar composite was analyzed and characterized by optical microscopy and scanning electron microscopy. The release kinetics of Gemzar from the proteinaceous microspheres was tested. The BSA-Gemzar composite was examined for its anticancer activity (in vitro) in renal cancer cells (RCC, 786-O cells) using [H-3]thymidine incorporation assays. It was found that the influence of the Gemzar-loaded microspheres on the cancer cells was significantly greater than that of an equimolar concentration of pristine Gemzar. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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