Journal
ACTA BIOMATERIALIA
Volume 4, Issue 1, Pages 40-48Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2007.06.006
Keywords
drug delivery; folic acid receptor; functionalization; magnetite nanoparticles
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We describe here the chemical synthesis and in vitro drug delivery response of polyethylene glycol (PEG)-functionalized magnetite (Fe3O4) nanoparticles, which were activated with a stable ligand, folic acid, and conjugated with an anticancer drug, doxorubicin. The functionalization and conjugation steps in the chemical synthesis were confirmed using Fourier transform infrared spectroscopy. The drug-release behavior of PEG-functionalized and folic acid-doxorubicin-conjugated magnetic nanoparticles was characterized by two stages involving an initial rapid release, followed by a controlled release. (C) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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