Journal
ACTA BIOMATERIALIA
Volume 4, Issue 2, Pages 264-272Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2007.09.011
Keywords
drug encapsulation; scaffold; thermally induced phase separation; bioactive glass; antibacterial
Funding
- Medical Research Council [G0401378] Funding Source: Medline
- MRC [G0401378] Funding Source: UKRI
- Medical Research Council [G0401378] Funding Source: researchfish
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A novel application of thermally induced phase separation (TIPS) is described enabling the rapid formation of monodisperse porous microspheres. By taking advantage of TIPS processing parameters, the porosity, the pore morphology (bimodal/channel-like/radial towards the centre) and the presence of an open-pore or dense skin region can be tailored. Achievable sizes range from 10 to 2000 mu m in diameter. The technique facilitates the homogeneous inclusion of particulate fillers and drugs. Moreover, the combined TIPS/oil-in-water emulsion technique allows for the production of microspheres with isotropic pore morphology with interconnected spherical pores of 30-70 mu m and well-formed porous microspheres of 10-200 mu m in diameter with an open porous surface. This method is advantageous over existing techniques by avoiding the use of long-term exposure to an aqueous continuous phase as used in oil-in-water or water-in-oil-in-water processing and therefore drug encapsulation efficiencies will be higher. (C) 2007 Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
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