Journal
ACTA BIOMATERIALIA
Volume 4, Issue 3, Pages 733-744Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2007.12.004
Keywords
poly(aspartic acid); poly(succinimide); polymer gel; pH sensitivity; swelling
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Chemically cross-linked poly(aspartic acid) (PASP) gels were prepared by the hydrolysis of poly(succinimide) (PSI). The latter was prepared by thermal polycondensation of aspartic acid. The PSI chains were cross-linked by natural amines and amino acid derivatives such as putrescin, spermine, spermidine, lysine and cystamine to obtain biodegradable, biocompatible, amino acid-based hydrogels. The volume of the synthesized unhydrolyzed PSI gels changes abruptly at a well-defined pH that results in ring opening, while the hydrolyzed gels show a volume phase transition around the pK values of PASP. The unidirectional stress-strain behavior of the gels as well as the dependence of equilibrium swelling degree on the pH was carefully studied and the most important network parameters were determined by a modified version of the Brannon-Peppas-Peppas theory. (c) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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