Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 47, Issue 1, Pages 53-59Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmu114
Keywords
Hippo pathway; YAP; TAZ; mammary gland development; breast cancer
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Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01040406]
- National Natural Science Foundation of China [81072162, 81120108019, U1132605]
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Accumulated evidence suggests that the Hippo signaling pathway plays crucial roles in mammary gland development and breast cancer. Key components of the Hippo pathway regulate breast epithelial cell proliferation, migration, invasion, and stemness. Additionally, the Hippo pathway regulates breast tumor growth, metastasis, and drug resistance. It is expected that the Hippo pathway will provide novel therapeutic targets for breast cancer. This review will discuss and summarize the roles of several core components of the Hippo pathway in mammary gland development and breast cancer.
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