Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 45, Issue 11, Pages 963-972Publisher
SCIENCE PRESS
DOI: 10.1093/abbs/gmt106
Keywords
gastric cancer; miR-106a; PTEN
Categories
Funding
- National Natural Science Foundation of China [81070423]
- Natural Science Foundation of Jiangsu Province of China [BK2010332]
Ask authors/readers for more resources
Recent studies have shown that microRNA-106a (miR-106a) is overexpressed in gastric cancer and contributes to tumor growth. In this study, we investigated whether miR-106a mediated resistance of the gastric cancer cell line SGC7901 to the chemotherapeutic agent cisplatin (DDP). MiR-106a expression was up-regulated in the DDP resistant cell line SGC7901/DDP compared with its parental line SGC7901. Transfection of miR-106a induced DDP resistance in SGC7901, while suppression of miR-106a in SGC7901/DDP led to enhanced DDP cytotoxicity. Further study indicated that the mechanism of miR-106a-induced DDP resistance involved the expression of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) protein and its downstream phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathway. This study provides a novel mechanism of DDP resistance in gastric cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available