Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 42, Issue 5, Pages 318-324Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmq026
Keywords
miR-20a; ovarian carcinoma; colony formation; invasion; amyloid precursor protein (APP)
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Funding
- National Natural Science Foundation of China [30873017]
- Natural Science Foundation of Tianjin Province of China [08JCZDJC23300, 09JCZDJC17500]
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MicroRNAs (miRNAs) are emerging as a class of small regulated RNAs, and the alterations of miRNAs are implicated in the initiation and progression of human cancers. Our study shows that inhibition of miR-20a in OVCAR3 ovarian cancer cell line could suppress, whereas overexpression of miR-20a could enhance cell long- term proliferation and invasion. We also confirmed amyloid precursor protein (APP) as a direct target gene of miR20a. Furthermore, suppression of APP expression could also promote ovarian cancer cell proliferation and invasion, which is consistent with the results of miR-20a overexpression. Therefore, we concluded that the regulation of APP is an important mechanism for miR-20a to promote proliferation and invasion in ovarian cancer cells.
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