Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 41, Issue 6, Pages 437-445Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmp031
Keywords
lysosome; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease
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Funding
- Natural Science Foundation of Jiangsu Province [BK 2007548]
- Natural Science Foundation of China [30801391]
- Suzhou Social Progress Foundation [SS0729]
- Souzhou University doctor scientific research foundation [Q4134802]
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It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Abnormal protein degradation and deposition induced by lysosomal dysfunction may be the primary contributor to age-related neurodegeneration. In this review, the possible relationship between lysosome and various neurodegenerative diseases is described.
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