Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 41, Issue 7, Pages 527-534Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmp040
Keywords
Bmi-1; stem cell; self-renewal; cancer
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Funding
- Foundation of Ministry of Science and Technology of China [30670803, 30770836]
- Foundation of Ministry of Science and Technology of Guangdong Province, China [2008A030201006]
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Bmi-1, a polycomb gene family member, plays an important role in cell cycle regulation, cell immortalization, and cell senescence. Recently, numerous studies have demonstrated that Bmi-1 is involved in the regulation of self-renewal and differentiation of stem cells. However, the molecular mechanism underlying this biological process remains largely unclear. In the present review, we summarized the function of Bmi-1 as a transcriptional regulator of gene expression, with particular reference to stem cells.
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